Mild Cognitive Impairment: Incidence and Risk factors – Results of the Leipzig Longitudinal Study of the Aged (LEILA75+)
Claudia Sikorski,
Melanie Luppa, Tobias Luck, Steffi G. Riedel-Heller, Susanne Briel, Herbert
Matschinger
Institut für Sozialmedizin, Arbeitsmedizin und Public Health (ISAP),
Arbeitsgruppe Public Health: Epidemiologie und Versorgungsforschung
Universität Leipzig
Arno Villringer,
Max-Planck-Institut
für Kognitions- und Neurowissenschaften und Tagesklinik für kognitive
Neurologie; Leipzig
Hans-Helmut König,
Universitätsklinikum Hamburg-Eppendorf,
Zentrum für Psychosoziale Medizin, Institut für Medizinische Soziologie,
Sozialmedizin und Gesundheitsökonomie; Hamburg
1 . Zielsetzung/Fragestellung
Mild Cognitive Impairment (MCI) constitutes a pre-stage of dementia in many
cases. The aims of the present study were to estimate age- and gender-specific
incidence of MCI and to identify risk factors for incident MCI in a population-based
sample of cognitively healthy subjects aged 75 years and older.
2. Materialien/Methoden
Data were derived from the Leipzig Longitudinal Study of the Aged (LEILA75+),
a population-based study of individuals aged 75 years and older. Incidence
was calculated according to the ‘person-years-at-risk’ method.
Cox proportional hazards models were used to identify risk factors for incident
MCI.
3. Ergebnisse
During the 8-year follow-up period, roughly one fourth (n = 137; 26.4%) of
the population at risk developed MCI. The overall incidence of MCI for subjects
aged 75 years and older was 76.5 (95%-PCI = 64.7-90.4) per 1,000 person-years
(overall person-years = 1,791.08). The incidence rate was highest in age group
85+ years and higher in women than men (80.8, 95%-PCI = 66.6-98.0 vs. 65.8,
95%-PCI = 47.0-92.1). Cox proportional hazards model identified older age,
subjective memory complaints, impairment in instrumental activities of daily
living, and lower cognitive performance as significant risk factors for incident
MCI.
4. Zusammenfassung/Schlussfolgerung
MCI has high incidence in the elderly population. The inclusion of restrictions
in instrumental activities of daily living in the criteria of MCI particularly
might be useful to improve the prediction of dementia. Subjective memory complaints
in previously cognitively healthy individuals should be taken seriously as
a possible pre-stage of MCI.
This publication was funded by the
junior research grant by the Medical Faculty, University of Leipzig. The
field work was supported by the Interdisciplinary
Centre for Clinical Research Leipzig (project C07) and published with affiliation
of the Leipzig Interdisciplinary Research Cluster of Genetic Factors, Clinical
phenotypes and Environment (LIFE Center, Universität Leipzig). LIFE is
financed by means of the European Union, by the European Regional Development
Fund (ERDF) and by means of the Free State of Saxony within the framework of
the excellence initiative.