Age- and gender-specific
prevalence of depression in latest-life – Systematic
review and meta-analysis
Claudia Sikorski
Melanie
Luppa
Tobias Luck
Lena Ehreke
Institut für Sozialmedizin, Arbeitsmedizin und Public Health (ISAP),
Arbeitsgruppe Public Health: Epidemiologie und Versorgungsforschung
Universität Leipzig
Alexander
Konnopka, Universitätsklinikum
Hamburg-Eppendorf, Institut für Medizinische Soziologie, Sozialmedizin
und Gesundheitsökonomie (IMSG), Hamburg
Birgit Wiese, Medizinische Hochschule
Hannover, Institut für Biometrie, Hannover
Siegfried Weyerer, Zentralinstitut
für Seelische Gesundheit, Mannheim
Hans-Helmut König, Universitätsklinikum
Hamburg-Eppendorf, Institut für Medizinische Soziologie, Sozialmedizin
und Gesundheitsökonomie (IMSG), Hamburg
Steffi G. Riedel-Heller, Universität
Leipzig, Institut für Sozialmedizin, Arbeitsmedizin und Public Health
(ISAP), Leipzig
1 . Zielsetzung/Fragestellung
The objective of the study is to systematically analyze the prevalence of depression
in latest life (75+), particularly focusing on age- and gender-specific rates
across the latest-life age groups.
2. Materialien/Methoden
Relevant articles were identified by systematically searching the databases
MEDLINE,
Web of Science, Cochrane Library and Psycinfo and relevant literature from
1999 onwards was reviewed. Studies based on the community-based elderly population
aged 75 years and older were included. Quality of studies was assessed. Meta-analysis
was performed using random effects model.
3. Ergebnisse
24 studies reporting age- and gender-specific prevalence of depression were
found. 13 studies had a high to moderate methodical quality. The prevalence
of major depression ranged from 4.6% to 9.3%, and that of depressive disorders
from 4.5% to 37.4%. Pooled prevalence was 7.2% (95% CI 4.4–10.6%) for
major depression and 17.1% (95% CI 9.7–26.1%) for depressive disorders.
Potential sources of high heterogeneity of prevalence were study design, sampling
strategy, study quality and applied diagnostics of latest life depression.
4. Zusammenfassung/Schlussfolgerung
Despite the wide variation in estimates, it is evident that latest life depression
is common. To reduce variability of study results, particularly sampling strategies
(inclusion of nursing home residents and severe cognitively impaired individuals)
for the old age study populations should be addressed more thoroughly in future
research.